Author (Year) Groups Studied and Intervention Results and Findings Conclusions
Jia et al. (2020)[@123973] A group of 30 patients with idiopathic GN treated with CT guided radiofrequency ablation were retrospectively investigated to determine the long-term outcomes of the treatment Those with satisfactory pain relief:
93.3% at 12 months
89.6% at 24 months
85.3% at 36 months
79.6% at 48 months
73.0% at 60 months
73.0% at 72 months
54.8% at 84 months
54.8% at 108 months
54.8% at 120 months
Pulsed Radiofrequency is a safe and effective treatment option for those with GN that have failed medical management.
Bharti et al. (2018)[@123974] A group of 25 patients with pain in the distribution of the glossopharyngeal nerve underwent fluoroscopy guided pulsed radiofrequency (PRF) ablation. Significant reduction in site specific pain, odynophagia, and ear pain for all patients. All patients also reported better sleep, decreased nausea and vomiting, and lesser opioid consumption. Pain relief lasted an average of 5-9 months. PRF is safe and effective at reducing pain in patients with oropharyngeal carcinoma causing GN.
Liu et al. (2019)[@123975] A total of 12 patients from First People’s Hospital with GN who received an ultrasound guided nerve block (total of 48 injections with 0.5% lidocaine and 40 mg methylprednisolone) were retrospectively analyzed to determine pain reduction. Pain relief effective rate (determined by decrease in VAS score by >2 points):
Discharge – 83.3%
6 months – 83.3%
12 months – 58.3%
18 months – 33.3%
Ultrasound guided nerve block of the glossopharyngeal nerve is a safe and effective treatment option for those experiencing GN who have failed medical management
Schuster et al. (2018)[@123976] A 51-year-old woman diagnosed with glossopharyngeal shingles who failed medical management received a fluoroscopic guided glossopharyngeal nerve block. After a nerve block with 2 mL 0.25% bupivacaine and 10 mg dexamethasone and then one again at 2 weeks and then 4 months after that, the patient experienced multiple weeks of significant pain relief from the GN. A glossopharyngeal nerve block was effective at reducing pain from GN in at least one woman with postherpetic neuralgia.
Wang et al. (2016)[@123977] A total of 71 patients with GN were retrospectively analyzed after receiving CT guided percutaneous radiofrequency thermocoagulation (PRT) for pain reduction. Pain reduction (determined by telephone):
Immediate post-op: 78.8%
Those remaining in “excellent” or “good” pain relief:
73.2% at 1 year
63.0% at 3 years
53.2% at 5 years
43.0% at 10 years
CT guided PRT is a safe and effective method for long term pain relief in those suffering from GN who have failed medical management.
Song et al. (2019)[@123978] A total of 117 patients with GN were retrospectively analyzed after receiving treatment with CT guided PRT. 82.1% of patients had “excellent” relief of pain immediately following intervention
Those experiencing “excellent” pain relief:
75.9% at 1 year
63.0% at 3 years
54.0% at 5 years
44.2% at 10 years
39.3% at 12.5 years
Adverse events due to intervention that were resolved by 12.9 +/- 5.1 weeks: abnormal sense of taste, larynx and pharynx numbness, hoarseness, and dysphagia.
CT guided PRT is a safe and effective method for long term pain relief in those suffering from GN who have failed medical management.